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HomeFeatured
\nChronic Fatigue Syndrome Is Not in Your Head, It\u2019s in Your Gut
\nNeuroscience NewsNEUROSCIENCE NEWSJUNE 27, 2016
\nFEATUREDNEUROLOGYOPEN NEUROSCIENCE ARTICLES6 MIN READ<\/p>\n
Summary: Researchers have identified biomarkers for chronic fatigue syndrome in gut bacteria and in inflammatory microbial agents in the blood.<\/p>\n
Source: Cornell University.<\/p>\n
Physicians have been mystified by chronic fatigue syndrome, a condition where normal exertion leads to debilitating fatigue that isn\u2019t alleviated by rest. There are no known triggers, and diagnosis requires lengthy tests administered by an expert.<\/p>\n
Now, for the first time, Cornell University researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood.<\/p>\n
In a study published June 23 in the journal Microbiome, the team describes how they correctly diagnosed myalgic encephalomyeletis\/chronic fatigue syndrome (ME\/CFS) in 83 percent of patients through stool samples and blood work, offering a noninvasive diagnosis and a step toward understanding the cause of the disease.<\/p>\n
\u201cOur work demonstrates that the gut bacterial microbiome in chronic fatigue syndrome patients isn\u2019t normal, perhaps leading to gastrointestinal and inflammatory symptoms in victims of the disease,\u201d said Maureen Hanson, the Liberty Hyde Bailey Professor in the Department of Molecular Biology and Genetics at Cornell and the paper\u2019s senior author. \u201cFurthermore, our detection of a biological abnormality provides further evidence against the ridiculous concept that the disease is psychological in origin.\u201d<\/p>\n
\u201cIn the future, we could see this technique as a complement to other noninvasive diagnoses, but if we have a better idea of what is going on with these gut microbes and patients, maybe clinicians could consider changing diets, using prebiotics such as dietary fibers or probiotics to help treat the disease,\u201d said Ludovic Giloteaux, a postdoctoral researcher and first author of the study.<\/p>\n
In the study, Ithaca campus researchers collaborated with Dr. Susan Levine, an ME\/CFS specialist in New York City, who recruited 48 people diagnosed with ME\/CFS and 39 healthy controls to provide stool and blood samples.<\/p>\n
The researchers sequenced regions of microbial DNA from the stool samples to identify different types of bacteria. Overall, the diversity of types of bacteria was greatly reduced and there were fewer bacterial species known to be anti-inflammatory in ME\/CFS patients compared with healthy people, an observation also seen in people with Crohn\u2019s disease and ulcerative colitis.<\/p>\n
Image shows gut bacteria.
\nThe researchers sequenced regions of microbial DNA from the stool samples to identify different types of bacteria. Overall, the diversity of types of bacteria was greatly reduced and there were fewer bacterial species known to be anti-inflammatory in ME\/CFS patients compared with healthy people, an observation also seen in people with Crohn\u2019s disease and ulcerative colitis. NeuroscienceNews.com image is for illustrative purposes only.
\nAt the same time, the researchers discovered specific markers of inflammation in the blood, likely due to a leaky gut from intestinal problems that allow bacteria to enter the blood, Giloteaux said.<\/p>\n
Bacteria in the blood will trigger an immune response, which could worsen symptoms.<\/p>\n
The researchers have no evidence to distinguish whether the altered gut microbiome is a cause or a whether it is a consequence of disease, Giloteaux added.<\/p>\n
In the future, the research team will look for evidence of viruses and fungi in the gut, to see whether one of these or an association of these along with bacteria may be causing or contributing to the illness.<\/p>\n
ABOUT THIS NEUROLOGY RESEARCH ARTICLE
\nFunding: The study was funded by the National Institutes of Health.<\/p>\n
Source: Melissa Osgood \u2013 Cornell University
\nImage Source: This NeuroscienceNews.com image is in the public domain.
\nOriginal Research: Full open access research for for \u201cReduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis\/chronic fatigue syndrome\u201d by Ludovic Giloteaux, Julia K. Goodrich, William A. Walters, Susan M. Levine, Ruth E. Ley and Maureen R. Hanson in Microbiome. Published online June 23 2016 doi:10.1186\/s40168-016-0171-4<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
http:\/\/neurosciencenews.com\/chronic-fatigue-microbiome-4581\/ HomeFeatured Chronic Fatigue Syndrome Is Not in Your Head, It\u2019s in Your Gut Neuroscience NewsNEUROSCIENCE NEWSJUNE 27, 2016 FEATUREDNEUROLOGYOPEN NEUROSCIENCE ARTICLES6 MIN READ Summary: Researchers have identified biomarkers for chronic fatigue syndrome in gut bacteria and in inflammatory microbial agents in the blood. Source: Cornell University. Physicians have been mystified by chronic fatigue … Continue reading “ChRon-iK FaTi-Gue SynDro-me is NoT in YouR H34D, is in Yo\u00fcR G\u00dcT”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"link","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-158","post","type-post","status-publish","format-link","hentry","category-uncategorized","post_format-post-format-link"],"yoast_head":"\nChRon-iK FaTi-Gue SynDro-me is NoT in YouR H34D, is in Yo\u00fcR G\u00dcT - N3WZ bakteria.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bakteria.org\/N3WZ\/chron-ik-fati-gue-syndro-me-is-not-in-your-h34d-is-in-your-gut\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ChRon-iK FaTi-Gue SynDro-me is NoT in YouR H34D, is in Yo\u00fcR G\u00dcT - N3WZ bakteria.org\" \/>\n<meta property=\"og:description\" content=\"http:\/\/neurosciencenews.com\/chronic-fatigue-microbiome-4581\/ HomeFeatured Chronic Fatigue Syndrome Is Not in Your Head, It\u2019s in Your Gut Neuroscience NewsNEUROSCIENCE NEWSJUNE 27, 2016 FEATUREDNEUROLOGYOPEN NEUROSCIENCE ARTICLES6 MIN READ Summary: Researchers have identified biomarkers for chronic fatigue syndrome in gut bacteria and in inflammatory microbial agents in the blood. 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